AKR1C2/3-IN-1
AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity[1].
Product Specifications
CAS Number
3107747-45-2
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c2-3-in-1.html
Smiles
O=C(C(C1=O)=CC2=C(O1)C=C(O)C=C2)N(CC)CC
Molecular Formula
C14H15NO4
Molecular Weight
261.27
References & Citations
[1]Jonnalagadda S, et al. Coumarin-based Aldo-Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors. ChemMedChem. 2024 Jul 8:e202400081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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