DEC-RVRK-CMK (TFA)
Product Specifications
UNSPSC Description
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].
Target Antigen
Furin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dec-rvrk-cmk-tfa.html
Purity
96.66
Solubility
H2O : 5 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](C(CCl)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCC)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Weight
744.41 (free base)
References & Citations
[1]Wheatley JL, et al. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6626-31.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5062A/DEC-RVRK-CMK-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5062A/DEC-RVRK-CMK-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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