DEC-RVRK-CMK (TFA)

DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM) . The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].

Product Specifications

Product Name Alternative

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone (TFA)

UNSPSC

12352209

Target

Furin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dec-rvrk-cmk-tfa.html

Purity

96.66

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](C(CCl)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCC)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C34H66ClN11O5.xC2HF3O2

Molecular Weight

744.41 (free base)

References & Citations

[1]Wheatley JL, et al. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A. 2007 Apr 17;104 (16) :6626-31.