PROTAC AR Degrader-5
PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein ; black: linker (HY-169966) ; Blue: E3 ligase ligand (HY-125845) ).
Product Specifications
CAS Number
2703021-51-4
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/protac-ar-degrader-5.html
Solubility
10 mM in DMSO
Smiles
S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
Molecular Formula
C52H54F4N8O7S2
Molecular Weight
1043.16
References & Citations
[1]YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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