γ-Neuropeptide (rabbit)

γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release[1][2][3].

Product Specifications

CAS Number

[114882-65-4]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/γ-neuropeptide-rabbit.html

Purity

99.99

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC(C[C@H](N)C(N[C@@H](C)C(NCC(N[C@@H](CC1=CN=CN1)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C99H158N34O29S

Molecular Weight

2320.59

References & Citations

[1]Kage R, et al. Neuropeptide-gamma: a peptide isolated from rabbit intestine that is derived from gamma-preprotachykinin. J Neurochem. 1988 May;50 (5) :1412-7. |[2]Yuan L, et al. Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit. Pulm Pharmacol Ther. 1998 Feb;11 (1) :31-9. |[3]Debeljuk L, et al. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides. 1999;20 (2) :285-99. |[4]Kalra PS, et al. Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action. Endocrinology. 1992 Sep;131 (3) :1195-201. |[5]Debeljuk L, et al. In vivo and in vitro effects of neuropeptide K and neuropeptide gamma on the release of growth hormone. Neuroreport. 1995 Dec 15;6 (18) :2457-60.