HT-0712
HT-0712 is a Phosphodiesterase Type 4 (PDE4) inhibitor. HT-0712 enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia[1][2].
Product Specifications
CAS Number
[617720-02-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ht-0712.html
Smiles
COC1=C(C=C([C@@H]2C[C@H](C(NC2)=O)CC3=CC(C)=CC=C3)C=C1)OC4CCCC4
Molecular Formula
C25H31NO3
Molecular Weight
393.52
Precautions
P261-P280-P302+P352
References & Citations
[1]Marco Peters, et al. The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice. Neuropsychopharmacology. 2014 Dec;39 (13) :2938-48.|[2]Erin MacDonald, et al. A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. Neurorehabil Neural Repair. 2007 Nov-Dec;21 (6) :486-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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