Glucocorticoid receptor modulator 1
Product Specifications
UNSPSC Description
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice[1].
Target Antigen
AP-1; Glucocorticoid Receptor; NF-κB
Type
Reference compound
Related Pathways
Immunology/Inflammation;NF-κB;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glucocorticoid-receptor-modulator-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C=C(C(C)=C1)Cl)S(=O)(NC2=CC=C3C(CCCN3C(C4=CC=CC=C4)=O)=C2)=O
Molecular Weight
470.97
References & Citations
[1]Li D, Hou T, et al. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem. 2022 Nov 18.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151876/Glucocorticoid-receptor-modulator-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151876/Glucocorticoid-receptor-modulator-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2868357-11-1
Available Sizes
Curated Selection
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