Benzo[a]pyrene-d12
Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].
Product Specifications
CAS Number
63466-71-7
UNSPSC
12352005
Hazard Statement
H317, H340, H350, H360, H410
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.30
Solubility
10 mM in DMSO
Smiles
[2H]C1=C2C([2H])=C([2H])C([2H])=C3C([2H])=C([2H])C4=C([2H])C5=C([2H])C([2H])=C([2H])C([2H])=C5C(C4=C32)=C1[2H]
Molecular Formula
C20D12
Molecular Weight
264.38
Precautions
H317, H340, H350, H360, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4- (N-methyl-N-nitrosamino) -1- (3-pyridyl) -1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30 (3) : 209–216.|[3]Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo (a) pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5812:189
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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