Genistin

Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway[1][2][3].

Product Specifications

CAS Number

[529-59-9]

Product Name Alternative

Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Estrogen Receptor/ERR

Type

Natural Products

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Genistin.html

Purity

98.05

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C(C1=CC=C(O)C=C1)=COC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=C4)C2=C4O

Molecular Formula

C21H20O10

Molecular Weight

432.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi YR, et al. Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent. Molecules. 2020;25 (9) :2042. Published 2020 Apr 27.|[2]Liang Y, et al. A Comprehensive Screening and Identification of Genistin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-HRMS Analysis. Molecules. 2018;23 (8) :1862. Published 2018 Jul 26.|[3]Hwang ST, et al. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway [published online ahead of print, 2020 Oct 16]. Life Sci. 2020;263:118594.