(-) -JM-1232

(-) -JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-) -JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-) -JM-1232 can be used in research related to pain and analgesia[1][2].

Product Specifications

CAS Number

[1013427-48-9]

Product Name Alternative

MR04A3

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-jm-1232.html

Smiles

O=C(N1CCN(CC1)C)C[C@@H]2C3=C(C=C4C(CCC4)=C3)C(N2C5=CC=CC=C5)=O

Molecular Formula

C24H27N3O2

Molecular Weight

389.49

References & Citations

[1]Nishiyama T, et al. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol. 2008 Oct 31;596 (1-3) :56-61. |[2]Chiba S, et al. The antinociceptive effects and pharmacological properties of JM-1232 (-) : a novel isoindoline derivative. Anesth Analg. 2009 Mar;108 (3) :1008-14.