Ruthenium red

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].

Product Specifications

CAS Number

[11103-72-3]

Product Name Alternative

Ammoniated ruthenium oxychloride

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Dye Reagents

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ruthenium-red.html

Purity

99.95

Solubility

H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[NH3][Ru](O[Ru]([NH3])([NH3])([NH3])([NH3])O[Ru]([NH3])([NH3])([NH3])([NH3])[NH3])([NH3])([NH3])([NH3])[NH3].[6+].[Cl-].[6]

Molecular Formula

[ (NH3) 5RuORu (NH3) 4ORu (NH3) 5]Cl6

Molecular Weight

786.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Lashanda N Waller, et al. Ruthenium red staining for ultrastructural visualization of a glycoprotein layer surrounding the spore of Bacillus anthracis and Bacillus subtilis. J Microbiol Methods. 2004 Jul;58 (1) :23-30.|[2]Claire O Malécot, et al. Ruthenium red as an effective blocker of calcium and sodium currents in guinea-pig isolated ventricular heart cells. Br J Pharmacol. 1998 Jun; 124 (3) : 465-472.