PF-3166
PF-3166 is a PAD2 inhibitor (IC50=150 nM) that is competitive with Ca2+. TPF-3166 insignificantly inhibits PAD3 or PAD4 (80 μM) . PF-3166 also inhibits NH3 release (IC50=580 nM) .[1].
Product Specifications
UNSPSC
12352005
Target
Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-3166.html
Smiles
O=C([C@@H]1N(CC2=CC=C3C(N([C@H](C4=CC=CC=C4Br)CC(NC5=CC(NS(=O)(C)=O)=CC=C5C)=O)C(C6=CC=CC(OC7=CC=C(Cl)C=C7)=C6)=N3)=C2)CCC1)NC
Molecular Formula
C43H42BrClN6O5S
Molecular Weight
870.25
References & Citations
[1]Byrnes LJ, et al. Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism. ACS Chem Biol. 2024 Oct 18;19 (10) :2186-2197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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