NCX4040
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects[1].
Product Specifications
CAS Number
[287118-97-2]
Product Name Alternative
NO-Aspirin
UNSPSC
12352005
Hazard Statement
H317, H318
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ncx4040.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1=CC=C(CO[N+]([O-])=O)C=C1)C2=CC=CC=C2OC(C)=O
Molecular Formula
C16H13NO7
Molecular Weight
331.28
Precautions
H317, H318
References & Citations
[1]Somaiah Chinnapaka, et al. Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H 2 O 2) -mediated oxidative stress. Free Radic Biol Med. 2019 Nov 1;143:494-509.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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