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Cotinine (Standard)

Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-) -Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke[1]

Product Specifications

CAS Number

486-56-6

Product Name Alternative

(-) -Cotinine (Standard) ; (S) -Cotinine (Standard) ; NIH-10498 (Standard)

UNSPSC

12352005

Target

Endogenous Metabolite; nAChR; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cotinine-standard.html

Smiles

O=C1N(C)[C@H](C2=CC=CN=C2)CC1

Molecular Formula

C10H12N2O

Molecular Weight

176.22

References & Citations

[1]Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug;5 (4) :473-83.|[2]Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb;50 (2) :128-36.|[3]Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-) -cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137 (3) : 313-318.|[4]Dwoskin L P, et al. (S) - (−) -Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288 (3) : 905-911.|[5]Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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