Histamine N-Methyl Transferase (HNMT)

<strong>Histamine N-Methyl Transferase (HNMT)</strong>_x000D_ <strong>Catalog number:</strong> B2013479_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 50-100 U/mg_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Histamine N-Methyl Transferase_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Jiménez EM, Å»oÅ‚ek T, Hernández Perez PG, Miranda Ruvalcaba R, Nicolás-Vázquez MI, Hernández-Rodríguez M. Drug Repurposing to Inhibit Histamine N-Methyl Transferase Molecules. 2023 Jan 6;28(2):576._x000D_ 2: García-Martín E, Martínez C, Benito-León J, Calleja P, Díaz-Sánchez M, Pisa D, Alonso-Navarro H, Ayuso-Peralta L, Torrecilla D, Agúndez JA, Jiménez-Jiménez FJ. Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis Eur J Neurol. 2010 Feb;17(2):335-8._x000D_ 3: García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ. Histamine-N-methyl transferase polymorphism and risk for migraine Headache. 2008 Oct;48(9):1343-8._x000D_ 4: Ichinose W, Sawato T, Kitano H, Shinozaki Y, Arisawa M, Saito N, Yoshikawa T, Yamaguchi M. Optically active iodohelicene derivatives exhibit histamine N-methyl transferase inhibitory activity J Antibiot (Tokyo). 2019 Jun;72(6):476-481._x000D_ 5: Futo J, Kupferberg JP, Moss J. Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants Biochem Pharmacol. 1990 Feb 1;39(3):415-20._x000D_ 6: Jiménez-Jiménez FJ, García-Martín E, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, Agúndez JA. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome J Neural Transm (Vienna). 2017 Mar;124(3):285-291._x000D_ 7: Vinod PK, Konkimalla B, Chandra N. In-silico pharmacodynamics: correlation of adverse effects of H2-antihistamines with histamine N-methyl transferase binding potential Appl Bioinformatics. 2006;5(3):141-50._x000D_ 8: Sachidanandam K, Gayle AA, Robins HI, Kolesar JM. Unexpected doxorubicin-mediated cardiotoxicity in sisters: possible role of polymorphisms in histamine n-methyl transferase J Oncol Pharm Pract. 2013 Sep;19(3):269-72._x000D_ 9: Crooks PA, Hassan SF, Benghiat E, Hemrick-Luecke SK, Fuller RW. 5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase Drug Metabol Drug Interact. 1989;7(2-3):111-41._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/8689395">10: Valen G, Kaszaki J, Szabo I, Nagy S, Vaage J. Activity of histamine metabolizing and catabolizing enzymes during reperfusion of isolated, globally ischemic rat hearts Inflamm Res. 1996 Mar;45(3):145-9. </a>_x000D_ _x000D_ <strong>Products Related to Histamine N-Methyl Transferase (HNMT) can be found at</strong> <a href="https://moleculardepot.com/product-category/Enzymes/"> Enzymes</a>