DWIZ-1
DWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ (ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) [1].
Product Specifications
UNSPSC
12352005
Target
Histone Acetyltransferase; Molecular Glues
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dwiz-1.html
Purity
98.00
Smiles
O=C([C@@H](N(CC1=C2C=CC(O[C@@H]([C@@H]3N(CC)CCCC3)C)=C1)C2=O)CC4)NC4=O
Molecular Formula
C22H29N3O4
Molecular Weight
399.48
References & Citations
[1]Ting PY, et al. A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science. 2024 Jul 5;385 (6704) :91-99.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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