EAD1 (TFA)

EAD1 TFA is an aluminum-activated malate transporter with activity in regulating corn ear development. EAD1 TFA is preferentially expressed in the xylem of immature ears and localized across the plasma membrane. The EAD1 TFA transports malic acid in the apical part of developing inflorescences, and its deletion results in reduced malic acid content in this part. The overexpression of EAD1 TFA was significantly positively correlated with ear length and the number of kernels per row. EAD1 TFA serves as a potential genetic resource to help improve grain yield in maize[1].

Product Specifications

CAS Number

[2320427-95-8]

UNSPSC

12352101

Target

Apoptosis; Autophagy

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ead1-tfa.html

Smiles

O=C(C(F)(F)F)O.ClC1=CC=C(CN2N=NC(CNCCN(CCNC3=C4C=CC(Cl)=CC4=NC=C3)C)=C2)C=C1

Molecular Formula

C26H28Cl2F3N7O2

Molecular Weight

598.45

References & Citations

[1]Lars Ulrik Nordstrøm, et al. Discovery of Autophagy Inhibitors With Antiproliferative Activity in Lung and Pancreatic Cancer Cells. ACS Med Chem Lett. 2015 Jan 8;6 (2) :134-9.|[2]EAR APICAL DEGENERATION1 regulates maize ear development by maintaining malate supply for apical inflorescence