(±) -Perillaldehyde

(±) -Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±) -Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM[1][2].

Product Specifications

CAS Number

[2111-75-3]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

JNK; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-perillaldehyde.html

Purity

96.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1CCC(C=O)=CC1)=C

Molecular Formula

C10H14O

Molecular Weight

150.22

Precautions

H315, H319, H335

References & Citations

[1]N Ito, et al. Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System. Evid Based Complement Alternat Med. 2011:2011:512697.|[2]Takuya Uemura, et al. Intestinal Anti-Inflammatory Activity of Perillaldehyde. J Agric Food Chem. 2018 Apr 4;66 (13) :3443-3448.