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Feprazone (Standard)

Feprazone (Standard) is the analytical standard of Feprazone. This product is intended for research and analytical applications. Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone , is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX) -2. Feprazone ameliorates free fatty acid (FFA) -induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity[1][2][3].

Product Specifications

CAS Number

30748-29-9

Product Name Alternative

DA2370 (Standard) ; Prenazone (Standard) ; Zepelin (Standard)

UNSPSC

12352005

Target

COX; MMP; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/feprazone-standard.html

Smiles

O=C(N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)C1C/C=C(C)\C

Molecular Formula

C20H20N2O2

Molecular Weight

320.39

References & Citations

[1]Song M, et al. Feprazone Prevents Free Fatty Acid (FFA) -Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway. ACS Omega. 2021 Feb 9;6 (7) :4850-4856.|[2]Fletcher MR, et al. Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance. Ann Rheum Dis. 1975 Apr;34 (2) :190-4.|[3]Che L, et al. Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. ACS Omega. 2021 Mar 7;6 (10) :6674-6680.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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