Pumosetrag Hydrochloride

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Product Specifications

CAS Number

[194093-42-0]

Product Name Alternative

MKC-733; DDP-733

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Pumosetrag_Hydrochloride.html

Purity

99.77

Solubility

DMSO : 12 mg/mL (ultrasonic) |H2O : 2.94 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl

Molecular Formula

C15H18ClN3O2S

Molecular Weight

339.84

References & Citations

[1]Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81 (2) :104-9. Epub 2007 Oct 19.|[2]Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18 (10) :1039-48.