Pumosetrag Hydrochloride
Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
Product Specifications
CAS Number
[194093-42-0]
Product Name Alternative
MKC-733; DDP-733
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Pumosetrag_Hydrochloride.html
Purity
99.77
Solubility
DMSO : 12 mg/mL (ultrasonic) |H2O : 2.94 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl
Molecular Formula
C15H18ClN3O2S
Molecular Weight
339.84
References & Citations
[1]Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81 (2) :104-9. Epub 2007 Oct 19.|[2]Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18 (10) :1039-48.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Lactoferrin
Available Sizes
Curated Selection
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