N 0861

N-0861 is a novel selective A1 adenosine receptor antagonist. In studies, it has been shown to be able to inhibit the negative conduction effects (prolonged AH interval) and chest pain caused by adenosine, while having no significant effect on the increase in coronary blood flow velocity caused by adenosine. This indicates that N-0861 has the property of selectively inhibiting A1 adenosine receptors[1].

Product Specifications

CAS Number

[141696-90-4]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-0861.html

Smiles

CN(C=N1)C2=C1C(N[C@H]3[C@@H]4C[C@@H](CC4)C3)=NC=N2

Molecular Formula

C13H17N5

Molecular Weight

243.31

References & Citations

[1]Bertolet BD, et al. Selective attenuation by N-0861 (N6-endonorboran-2-yl-9-methyladenine) of cardiac A1 adenosine receptor-mediated effects in humans. Circulation. 1996 May 15;93 (10) :1871-6.