Safimaltib
Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis[1][2][3].
Product Specifications
CAS Number
[2230273-76-2]
Product Name Alternative
JNJ-67856633
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/safimaltib.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C(F)(F)F)N(C2=CC=CC3=C2C=CNC3=O)N=C1)NC4=CC(C(F)(F)F)=NC=C4
Molecular Formula
C20H11F6N5O2
Molecular Weight
467.32
Precautions
H302, H315, H319
References & Citations
[1]Virtual meeting delivers first time drug structures|[2]A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-67856633, an Inhibitor of MALT1, in Participants with NHL and CLL|[3]Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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