West Nile Virus NS3 Protease

<strong>West Nile Virus NS3 Protease</strong>_x000D_ <strong>Catalog number:</strong> B2011268_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 32 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80 °C_x000D_ <strong>Keywords:</strong> WNV Protease NS3_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Voss S, Nitsche C. Targeting the protease of West Nile virus RSC Med Chem. 2021 May 26;12(8):1262-1272._x000D_ 2: Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. West Nile Virus_NS2B/NS3 protease as an antiviral target Curr Med Chem. 2008;15(27):2771-84._x000D_ 3: Skoreński M, Milewska A, Pyrć K, Sieńczyk M, Oleksyszyn J. Phosphonate inhibitors of West Nile virus NS2B/NS3 protease J Enzyme Inhib Med Chem. 2019 Dec;34(1):8-14._x000D_ 4: Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Potential Dual Role of West Nile Virus_NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication Viruses. 2021 Jan 31;13(2):216._x000D_ 5: Akaberi D, Båhlström A, Chinthakindi PK, Nyman T, Sandström A, Järhult JD, Palanisamy N, Lundkvist Å, Lennerstrand J. Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors Antiviral Res. 2021 Jun;190:105074._x000D_ 6: Dražić T, Kopf S, Corridan J, Leuthold MM, Bertoša B, Klein CD. Peptide-β-lactam Inhibitors of Dengue and West Nile Virus_NS2B-NS3 Protease Display Two Distinct Binding Modes J Med Chem. 2020 Jan 9;63(1):140-156._x000D_ 7: Gayen S, Chen AS, Huang Q, Kang C. West Nile Virus (WNV) protease and membrane interactions revealed by NMR spectroscopy Biochem Biophys Res Commun. 2012 Jul 13;423(4):799-804._x000D_ 8: Kouretova J, Hammamy MZ, Epp A, Hardes K, Kallis S, Zhang L, Hilgenfeld R, Bartenschlager R, Steinmetzer T. Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication J Enzyme Inhib Med Chem. 2017 Dec;32(1):712-721._x000D_ 9: Rut W, Groborz K, Zhang L, Modrzycka S, Poreba M, Hilgenfeld R, Drag M. Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses Antiviral Res. 2020 Mar;175:104731._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30193218">10: Martinez AA, Espinosa BA, Adamek RN, Thomas BA, Chau J, Gonzalez E, Keppetipola N, Salzameda NT. Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor Eur J Med Chem. 2018 Sep 5;157:1202-1213. </a>_x000D_ _x000D_ <strong>Products Related to West Nile Virus NS3 Protease can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>