AG 1406
AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].
Product Specifications
CAS Number
[71308-34-4]
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ag-1406.html
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1
Molecular Formula
C16H18N2O
Molecular Weight
254.33
Precautions
H301, H311, H331
References & Citations
[1]Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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