Cholesterol hemisuccinate (Tris salt)

Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation[1][2][3][4].

Product Specifications

CAS Number

[102601-49-0]

Product Name Alternative

Cholesterol hydrogen succinate (Tris salt) ; CHS-Tris

UNSPSC

12352211

Target

Apoptosis; Biochemical Assay Reagents; DNA/RNA Synthesis; Necroptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cholesterol-hemisuccinate-tris-salt.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 18.75 mg/mL (ultrasonic)

Smiles

OCC(CO)(N)CO.C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C35H61NO7

Molecular Weight

607.86

References & Citations

[1]Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279 (3) :1470-83.|[2]Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.|[3]Mazur P, et al. In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem. 1996 Jun 14;271 (24) :14604-9.|[4]Ott D, et al. Engineering and functional immobilization of opioid receptors. Protein Eng Des Sel. 2005 Mar;18 (3) :153-60.|[5]Löw C, et al. Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1. PLoS One. 2012;7 (6) :e38244.|[6]Zhang L, et al. A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting. Int J Nanomedicine. 2012;7:151-62.