CE-224535
CE-224535 is a selective P2X7 receptor antagonist.
Product Specifications
CAS Number
724424-43-5
Product Name Alternative
PF-04905428
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CE-224535.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C[C@@H](O)COC)C(N(C2=CC=C(Cl)C(C(NCC3(O)CCCCCC3)=O)=C2)N=C1)=O
Molecular Formula
C22H29ClN4O6
Molecular Weight
480.94
References & Citations
[1]Stock TC, et al. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39 (4) :720-7.|[2]Duplantier AJ, et al. Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3708-11
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P2X7 Receptor
Available Sizes
Frequently Asked Questions
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