CE-224535

CE-224535 is a selective P2X7 receptor antagonist.

Product Specifications

CAS Number

[724424-43-5]

Product Name Alternative

PF-04905428

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CE-224535.html

Purity

98.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C[C@@H](O)COC)C(N(C2=CC=C(Cl)C(C(NCC3(O)CCCCCC3)=O)=C2)N=C1)=O

Molecular Formula

C22H29ClN4O6

Molecular Weight

480.94

References & Citations

[1]Stock TC, et al. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39 (4) :720-7.|[2]Duplantier AJ, et al. Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3708-11