DSM74

DSM74 (compound 21) is an orally active and potent antimalarial inhibitor of PfDHODH (IC50=0.28 μM) and PbDHODH (IC50=0.38 μM) . DSM74 inhibits the growth of Plasmodium in animals[1].

Product Specifications

CAS Number

[898743-92-5]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dsm74.html

Smiles

FC(F)(F)C1=CC=C(C=C1)NC2=CC(C)=NC3=NC=NN23

Molecular Formula

C13H10F3N5

Molecular Weight

293.25

References & Citations

[1]Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52 (7) : 1864-1872.