DSM74
DSM74 (compound 21) is an orally active and potent antimalarial inhibitor of PfDHODH (IC50=0.28 μM) and PbDHODH (IC50=0.38 μM) . DSM74 inhibits the growth of Plasmodium in animals[1].
Product Specifications
CAS Number
898743-92-5
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dsm74.html
Smiles
FC(F)(F)C1=CC=C(C=C1)NC2=CC(C)=NC3=NC=NN23
Molecular Formula
C13H10F3N5
Molecular Weight
293.25
References & Citations
[1]Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52 (7) : 1864-1872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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