Glucocorticoid receptor modulator 3

Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC50=0.6 nM) . Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases[1].

Product Specifications

CAS Number

[2688785-13-7]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/glucocorticoid-receptor-modulator-3.html

Smiles

O=C([C@@]1(OC(C2=CC(N)=C(C=C2)F)=O)[C@@H](C[C@@]3([C@]1(C)C[C@H](O)[C@]4(F)[C@@]5(C)C=CC(C=C5CC[C@]43[H])=O)[H])C)SCF

Molecular Formula

C29H32F3NO5S

Molecular Weight

563.63

References & Citations

[1]Marvin C C, et al. Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model[J]. Journal of Medicinal Chemistry, 2024.