Glucocorticoid receptor modulator 3
Product Specifications
UNSPSC Description
Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC50=0.6 nM). Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases[1].
Target Antigen
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glucocorticoid-receptor-modulator-3.html
Smiles
O=C([C@@]1(OC(C2=CC(N)=C(C=C2)F)=O)[C@@H](C[C@@]3([C@]1(C)C[C@H](O)[C@]4(F)[C@@]5(C)C=CC(C=C5CC[C@]43[H])=O)[H])C)SCF
Molecular Weight
563.63
References & Citations
[1]Marvin C C, et al. Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163672/Glucocorticoid-receptor-modulator-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163672/
Clinical Information
No Development Reported
CAS Number
2688785-13-7
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