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WRN inhibitor 15

WRN inhibitor 15 (Compound 9) is a WRN inhibitor with anti-tumor activity that can be used in prostate cancer research, the IC50 values are 37.9, 40.2 and 46.6 μM in PC3, LNCaP, and HeLa[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wrn-inhibitor-15.html

Smiles

CN(C1=CC=C(C=C1)O)C2=NC(C(F)F)=NC3=CC=CC=C32

Molecular Formula

C16H13F2N3O

Molecular Weight

301.29

References & Citations

[1]Jia Yu, et al. Quinazoline derivatives inhibit cell growth of prostate cancer as a WRN helicase dependent manner by regulating DNA damage repair and microsatellite instability. Bioorg Chem. 2024 Dec:153:107963.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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