WRN inhibitor 15
WRN inhibitor 15 (Compound 9) is a WRN inhibitor with anti-tumor activity that can be used in prostate cancer research, the IC50 values are 37.9, 40.2 and 46.6 μM in PC3, LNCaP, and HeLa[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-15.html
Smiles
CN(C1=CC=C(C=C1)O)C2=NC(C(F)F)=NC3=CC=CC=C32
Molecular Formula
C16H13F2N3O
Molecular Weight
301.29
References & Citations
[1]Jia Yu, et al. Quinazoline derivatives inhibit cell growth of prostate cancer as a WRN helicase dependent manner by regulating DNA damage repair and microsatellite instability. Bioorg Chem. 2024 Dec:153:107963.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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