Vesatolimod
Product Specifications
UNSPSC Description
Vesatolimod (GS-9620) is a potent, selective and orally active agonist of Toll-Like Receptor (TLR7) with an EC50 of 291 nM.
Target Antigen
Apoptosis; HBV; HCV; HIV; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GS-9620.html
Solubility
DMSO : ≥ 16.67 mg/mL
Smiles
O=C1NC2=C(N)N=C(OCCCC)N=C2N(CC3=CC=CC(CN4CCCC4)=C3)C1
Molecular Weight
410.51
References & Citations
[1]Rebbapragada I, et al. Molecular Determinants of GS-9620-Dependent TLR7 Activation. PLoS One. 2016 Jan 19;11(1):e0146835.|[2]Lanford RE, et al. GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees. Gastroenterology. 2013 Feb 13. pii: S0016-5085(13)00169-8.|[3]D Tumas, et al. Preclinical Characterization of GS-9620, A Potent and Selective Oral TLR7 Agonist.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15601/Vesatolimod-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15601/Vesatolimod-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1228585-88-3
Available Sizes
Curated Selection
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