MeS-IMPY

MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively) . [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET) [1][2].

Product Specifications

CAS Number

955376-42-8

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mes-impy.html

Smiles

CSC1=CN2C=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1

Molecular Formula

C16H17N3S

Molecular Weight

283.39

References & Citations

[1]Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34 (6) :681-9.|[2]Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2 (2) : 129-136.