[Ala11, D-Leu15]-Orexin B (human) (TFA)

[Ala11, D-Leu15]-Orexin B (human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11, D-Leu15]-Orexin B (human) TFA shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM) [1].

Product Specifications

UNSPSC

12352209

Target

Orexin Receptor (OX Receptor)

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ala11-d-leu15-orexin-b-human-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.O=C([C@H]1N(C(CNC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CO)=O)=O)CCC1)N2[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)[C@H](CC)C)=O)=O)C)=O)C)=O)=O)CC(N)=O)=O)=O)CO)=O)C)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)C)=O)CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)=O)CCC2.[x]

Molecular Formula

C120H206N44O35S.xC2HF3O2

Molecular Weight

2857.26 (free base)

References & Citations

[1]Asahi S, et al. Development of an orexin-2 receptor selective agonist, [Ala (11), D-Leu (15) ]orexin-B. Bioorg Med Chem Lett. 2003;13 (1) :111-113.