Ganfeborole (hydrochloride)
Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM.
Product Specifications
CAS Number
2131798-13-3
Product Name Alternative
GSK656; GSK3036656; GSK070
UNSPSC
12352005
Hazard Statement
H301, H373
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ganfeborole-hydrochloride.html
Purity
99.97
Solubility
DMSO : 67.5 mg/mL (ultrasonic)
Smiles
OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21.[H]Cl
Molecular Formula
C10H14BCl2NO4
Molecular Weight
293.94
Precautions
H301, H373
References & Citations
[1]Li X, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S) -3- (Aminomethyl) -4-chloro-7- (2-hydroxyethoxy) benzo[c][1,2]oxaborol-1 (3H) -ol (GSK656) . J Med Chem. 2017 Oct 12;60 (19) :8011-8026.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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