Ganfeborole (hydrochloride)

Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM.

Product Specifications

CAS Number

[2131798-13-3]

Product Name Alternative

GSK656; GSK3036656; GSK070

UNSPSC

12352005

Hazard Statement

H301, H373

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ganfeborole-hydrochloride.html

Purity

99.97

Solubility

DMSO : 67.5 mg/mL (ultrasonic)

Smiles

OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21.[H]Cl

Molecular Formula

C10H14BCl2NO4

Molecular Weight

293.94

Precautions

H301, H373

References & Citations

[1]Li X, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S) -3- (Aminomethyl) -4-chloro-7- (2-hydroxyethoxy) benzo[c][1,2]oxaborol-1 (3H) -ol (GSK656) . J Med Chem. 2017 Oct 12;60 (19) :8011-8026.