Thymine-13C5,15N2

Thymine-13C5,15N2 (5-Methyluacil-13C5,15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[1].

Product Specifications

CAS Number

[2483830-13-1]

Product Name Alternative

5-Methyluacil-13C5,15N2

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/thymine-13c5-15n2.html

Smiles

O=[13C]1[13C]([13CH3])=[13CH][15NH][13C]([15NH]1)=O

Molecular Formula

13C5H6 15N2O2

Molecular Weight

133.06

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.