Antibiofilm agent-12

Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model[1].

Product Specifications

CAS Number

[480452-24-2]

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibiofilm-agent-12.html

Smiles

O=C(NNC1=CC=C(Cl)C=C1)OC2=CC=CC=C2

Molecular Formula

C13H11ClN2O2

Molecular Weight

262.69

References & Citations

[1]Fatima T, et al. Exploring the antifungal potential of novel carbazate derivatives as promising drug candidates against emerging superbug, Candida auris. Bioorg Chem. 2024 Sep 4;153:107782.