Fluoxetine (hydrochloride)

Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.

Product Specifications

CAS Number

[56296-78-7]

Product Name Alternative

LY 110140

UNSPSC

12352005

Hazard Statement

H302, H318, H400

Target

Autophagy; Serotonin Transporter

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/fluoxetine-hydrochloride.html

Purity

99.97

Solubility

DMSO : ≥ 25 mg/mL|H2O : 8.33 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl

Molecular Formula

C17H19ClF3NO

Molecular Weight

345.79

Precautions

H302, H318, H400

References & Citations

[1]Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28 (9) :1562-71|[2]Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56 (8) :570-80.|[3]Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28 (6) :1374-84.|[4]Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl) . 2002 Apr;160 (4) :353-61|[5]Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23 (3) :250-62.|[6]Su WJ, et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14 (1) :210.