CDK13/Cyclin K GST-Tagged

<strong>CDK13/Cyclin K GST-Tagged</strong>_x000D_ <strong>Catalog number:</strong> B2017146_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80C_x000D_ <strong>Keywords:</strong> CDK13/Cyclin K GST-Tagged_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Greifenberg AK, Hönig D, Pilarova K, Düster R, Bartholomeeusen K, Bösken CA, Anand K, Blazek D, Geyer M. Structural and Functional Analysis of the Cdk13/Cyclin K Complex Cell Rep. 2016 Jan 12;14(2):320-31._x000D_ 2: Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K Nature. 2020 Sep;585(7824):293-297._x000D_ 3: Xiao Y, Dong J. Coming of Age: Targeting Cyclin K in Cancers Cells. 2023 Aug 11;12(16):2044._x000D_ 4: Kozicka Z, Suchyta DJ, Focht V, Kempf G, Petzold G, Jentzsch M, Zou C, Di Genua C, Donovan KA, Coomar S, Cigler M, Mayor-Ruiz C, Schmid-Burgk JL, Häussinger D, Winter GE, Fischer ES, Słabicki M, Gillingham D, Ebert BL, Thomä NH. Design principles for cyclin K molecular glue degraders Nat Chem Biol. 2024 Jan;20(1):93-102._x000D_ 5: Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, Wu Q, Li J, Wang JH, Dong MQ, Qi X, Han T. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation Elife. 2020 Aug 17;9:e59994._x000D_ 6: Sun R, Wei T, Ding D, Zhang J, Chen S, He HH, Wang L, Huang H. CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2205509119._x000D_ 7: Yu DS, Cortez D. A role for CDK9-cyclin K in maintaining genome integrity Cell Cycle. 2011 Jan 1;10(1):28-32._x000D_ 8: Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Rational discovery of molecular glue degraders via scalable chemical profiling Nat Chem Biol. 2020 Nov;16(11):1199-1207._x000D_ 9: Lei T, Zhang P, Zhang X, Xiao X, Zhang J, Qiu T, Dai Q, Zhang Y, Min L, Li Q, Yin R, Ding P, Li N, Qu Y, Mu D, Qin J, Zhu X, Xiao ZX, Li Q. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation Nat Commun. 2018 May 14;9(1):1876._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33042275">10: Yao G, Tang J, Yang X, Zhao Y, Zhou R, Meng R, Zhang S, Dong X, Zhang T, Yang K, Wu G, Xu S. Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer Theranostics. 2020 Sep 11;10(24):11144-11158. </a>_x000D_ _x000D_ <strong>Products Related to CDK13/Cyclin K GST-Tagged can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>