Acyclovir triphosphate (sodium)

Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP) . Acyclovir triphosphate sodium is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate sodium causes termination of viral DNA synthesis[1].

Product Specifications

CAS Number

[221119-43-3]

Product Name Alternative

AcycloGTP (sodium)

UNSPSC

12352200

Target

DNA/RNA Synthesis; HIV; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/acyclovir-triphosphate-sodium.html

Concentration

100 mM * 500 μL in water

Purity

99.71

Smiles

O=P(OP(OP(OCCOCN1C(N=C(N)NC2=O)=C2N=C1)(O)=O)(O)=O)(O)O.[x].[Na]

Molecular Formula

C8H14N5O12P3.xNa

References & Citations

[1]Hirsch MS, et al. Drug therapy: antiviral agents (second of two parts) . N Engl J Med. 1980 Apr 24;302 (17) :949-53. |[2]McMahon MA, et al. Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses. J Virol. 2011 May;85 (9) :4618-22.