β-Glucuronidase responsive conjugate 1

O=C(C1(CC1)C(NC2=CC=C(OC3=CC=NC4=CC(OCCOC(N(C)CCN(C(OCC5=CC=C(O[C@@H]6O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O)C=C5NC(CCC(NCCOCCOCCNC(C7=C(C)C8=CC9=[N]%10[Zn]%11%12N8C7=C(CC(OC)=O)C([C@@H](CCC(NCC%13=CN([C@H]%14[C@H](O)[C@@H](O)[C@H](O[C@H]%15O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%15O)[C@@H](CO)O%14)N=N%13)=O)[C@@H]%16C)=[N]%11C%16=CC%17=C(C)C(C=C)=C(N%17%12)C=C%10C(C)=C9CC)=O)=O)=O)=O)C)=O)=C(OC)C=C34)C=C2)=O)NC%18=CC=C(F)C=C%18

[1]Otvagin VF, et al. A first-in-class β-glucuronidase responsive conjugate for selective dual targeted and photodynamic therapy of bladder cancer. Eur J Med Chem. 2024 Mar 5;269:116283.