HDAC6-IN-48
HDAC6-IN-48 (compound 5i) is a potent and selective HDAC6 inhibitor with IC50 values of 5.16, 396.72, 638.08 nM for HDAC6, HDAC3, HDAC1, respectively. HDAC6-IN-48 induces apoptosis and cell cycle arrest at G0/G1 phase. HDAC6-IN-48 increases the protein expression of acetylated α-tubulin[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-48.html
Smiles
COC1=CC=C(C=C1)C2=CC3=C(NC=C3CC(NC4=CC=C(C=C4)C(NO)=O)=O)C=C2
Molecular Formula
C24H21N3O4
Molecular Weight
415.44
References & Citations
[1]Li X, et al. Discovery of Potent Selective HDAC6 Inhibitors with 5-Phenyl-1H-indole Fragment: Virtual Screening, Rational Design, and Biological Evaluation. J Chem Inf Model. 2024 Jul 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC3; HDAC6
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