A-953227

A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain) . A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1].

Product Specifications

CAS Number

1037826-77-9

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-953227.html

Smiles

O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=C(C=C3)F)NC(CC4=CC=CC=C4)C(C(N)=O)=O

Molecular Formula

C25H20FN5O3

Molecular Weight

457.46

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2- (3-Phenyl-1H-pyrazol-1-yl) -nicotinamides