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RF9

Product Specifications

UNSPSC Description

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

Target Antigen

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/RF9.html

Purity

98.24

Solubility

DMSO : 125 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)

Smiles

NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)C[C@H](C[C@H]4C3)C2)=O)=O)=O

Molecular Weight

482.62

References & Citations

[1]Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71.|[2]Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-107382/RF9-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-107382/RF9-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

876310-60-0

Available Sizes

Curated Selection

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