RF9

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].

Product Specifications

CAS Number

[876310-60-0]

UNSPSC

12352005

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/RF9.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)C[C@H](C[C@H]4C3)C2)=O)=O)=O

Molecular Formula

C26H38N6O3

Molecular Weight

482.62

References & Citations

[1]Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103 (2) :466-71.|[2]Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27 (4) :630-643.