SPDP
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].
Product Specifications
CAS Number
68181-17-9
Product Name Alternative
SPDP Crosslinker; Py-ds-Prp-OSu
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SPDP.html
Purity
99.14
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.37
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
Frequently Asked Questions
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