SPDP

SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].

Product Specifications

CAS Number

[68181-17-9]

Product Name Alternative

SPDP Crosslinker; Py-ds-Prp-OSu

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SPDP.html

Purity

99.14

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2

Molecular Formula

C12H12N2O4S2

Molecular Weight

312.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.