CVT-10216
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1].
Product Specifications
CAS Number
1005334-57-5
UNSPSC
12352005
Hazard Statement
H302
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cvt-10216.html
Concentration
10mM
Purity
99.87
Solubility
DMF : 25 mg/mL (ultrasonic; warming) |DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(O)C1=CC=CC(COC2=CC=C3C(C(C4=CC=C(NS(=O)(C)=O)C=C4)=COC3=C2)=O)=C1
Molecular Formula
C24H19NO7S
Molecular Weight
465.48
Precautions
H302
References & Citations
[1]Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94 (2) :255-61.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Synapsin III (SYN3) (NM_003490) Human Over-expression Lysate
Squalene Synthase (SQS) Activity Colorimetric Assay Kit
Squalene Synthase (SQS) Activity Colorimetric Assay Kit
