Zardaverine (Highly Pure)

<strong>Zardaverine (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2013535_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 268.2 g/mol_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Cartledge DM, Robbins KM, Drake KM, Sternberg R, Stabley DL, Gripp KW, Kolb EA, Sol-Church K, Napper AD. Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient Front Oncol. 2017 Apr 3;7:42._x000D_ 2: Schudt C, Winder S, Eltze M, Kilian U, Beume R. Zardaverine: a cyclic AMP specific PDE III/IV inhibitor Agents Actions Suppl. 1991;34:379-402._x000D_ 3: Schudt C, Winder S, Müller B, Ukena D. Zardaverine as a selective inhibitor of phosphodiesterase isozymes Biochem Pharmacol. 1991 Jun 21;42(1):153-62._x000D_ 4: Schermuly RT, Leuchte H, Ghofrani HA, Weissmann N, Rose F, Kohstall M, Olschewski H, Schudt C, Grimminger F, Seeger W, Walmrath D. Zardaverine and aerosolised iloprost in a model of acute respiratory failure Eur Respir J. 2003 Aug;22(2):342-7._x000D_ 5: Sun L, Quan H, Xie C, Wang L, Hu Y, Lou L. Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition PLoS One. 2014 Mar 5;9(3):e90627._x000D_ 6: Jeong J, Sa SJ, Chung H, Baek S, Choi I. A Dual Phosphodiesterase Inhibitor, Zardaverine (Type 3/4), Enhances Motility of Frozen-thawed Boar Sperm Cryo Letters. 2018 May/Jun;39(3):196-200._x000D_ 7: Kips JC, Joos GF, Peleman RA, Pauwels RA. The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats Clin Exp Allergy. 1993 Jun;23(6):518-23._x000D_ 8: Galvan M, Schudt C. Actions of the phosphodiesterase inhibitor zardaverine on guinea-pig ventricular muscle Naunyn Schmiedebergs Arch Pharmacol. 1990 Aug;342(2):221-7._x000D_ 9: Moniot A, Braux J, Siboni R, Guillaume C, Audonnet S, Allart-Simon I, Sapi J, Tirouvanziam R, Gérard S, Gangloff SC, Velard F. Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds Int J Mol Sci. 2022 Jun 29;23(13):7226._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/7925141">10: Hoymann HG, Heinrich U, Beume R, Kilian U. Comparative investigation of the effects of zardaverine and theophylline on pulmonary function in rats Exp Lung Res. 1994 May-Jun;20(3):235-50. </a>_x000D_ _x000D_ <strong>Products Related to Zardaverine (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Chemicals/"> Chemicals</a>